Tiazac XC (Diltiazem Hydrochloride)

Tiazac, known generically as diltiazem hydrochloride, is a calcium channel blocker medication primarily prescribed for the treatment of hypertension (high blood pressure), angina (chest pain), and certain types of arrhythmias (irregular heartbeats). It belongs to the class of medications known as calcium channel antagonists.Tiazac works by blocking the influx of calcium ions through specific channels in the cell membrane of cardiac and smooth muscle cells. By inhibiting calcium entry, Tiazac reduces the contractility of the heart muscle and dilates peripheral arteries, leading to decreased peripheral resistance and improved blood flow. This mechanism results in decreased blood pressure, relief of angina symptoms, and regulation of heart rhythm.Precautions and Warnings with Tiazac

• Allergies: Individuals with a known hypersensitivity to diltiazem or any other components of Tiazac should avoid its use.
• Acute Myocardial Infarction: Tiazac is contraindicated in patients with acute myocardial infarction and pulmonary congestion.
• Sick Sinus Syndrome: Tiazac is contraindicated in patients with sick sinus syndrome except in the presence of a functioning ventricular pacemaker.
• Heart Conditions: Patients with certain heart conditions, such as severe bradycardia (slow heart rate), atrioventricular block, and severe heart failure, require careful monitoring when using Tiazac.
• Liver and Kidney Impairment: Individuals with liver or kidney impairment may require dosage adjustments or close monitoring due to the potential for increased drug concentrations and prolonged effects of Tiazac.
• Hypotension: Tiazac should be used cautiously in patients prone to hypotension (low blood pressure) or those at risk of developing it.

Drug Interactions: with TiazacTiazac may interact with other medications, supplements, or substances, potentially affecting its effectiveness or increasing the risk of adverse effects. Some notable drug interactions with Tiazac may include:

• Advair diskus (fluticasone / salmeterol)
• Aspirin
• Aspirin low strength (aspirin)
• Clonazepam
• Lipitor
• Metoprolol
• Trazodone
• Xanax (alprazolam)
• Zoloft (sertraline)

Dosages For Conditions

• Hypertension (High Blood Pressure): The usual starting dose of Tiazac for hypertension is 180 mg to 240 mg once daily. The dose may be titrated up to a maximum of 540 mg daily, depending on individual patient response and blood pressure control.
• Chronic Stable Angina: The typical starting dose of Tiazac for chronic stable angina is 180 mg to 240 mg once daily. The dose may be increased up to a maximum of 360 mg daily based on the patient’s anginal symptoms and tolerance.
• Other Indications: Dosage adjustments may be necessary in patients with hepatic or renal impairment, elderly patients, and those receiving concomitant medications that may interact with Tiazac.

Dosage Administration

• Tiazac capsules should be swallowed whole and not crushed, chewed, or opened.
• The capsules should be taken once daily, preferably in the morning with or without food, as directed by a healthcare provider.
• It is essential to adhere to the prescribed dosage regimen and not exceed the recommended maximum daily dose unless instructed by a healthcare professional.

Cost of Tiazac in AmericaAt this time of writing, the cost for Tiazac oral capsule, extended release (120 mg/24 hours) to be approximately $72 for a supply of 30 capsules.Patients are encouraged to check with their local pharmacies, insurance providers, or explore patient assistance programs to determine the most cost-effective option for obtaining Tiazac.Why is Tiazac so Expensive?

• Brand Name Medication: Tiazac is available as a brand-name medication, which typically comes with a higher price tag compared to generic alternatives.
• Research and Development Costs: The development of pharmaceutical drugs involves significant research and development (R&D) expenses, which are often factored into the pricing of the medication.
• Patent Protection: Brand-name medications like Tiazac are often protected by patents, which grant exclusive rights to the manufacturer to market and sell the drug for a specified period. During this time, generic versions of the medication cannot be produced, allowing the manufacturer to set higher prices.
• Regulatory Costs: Pharmaceutical companies incur various regulatory costs associated with obtaining approval from regulatory agencies such as the Food and Drug Administration (FDA) in the United States. These costs are also reflected in the pricing of the medication.
• Marketing and Distribution Expenses: Pharmaceutical companies invest substantially in the marketing and distribution efforts to promote their brand-name medications, which adds to the overall cost of the drug.

Tiazac Alternatives:While Tiazac is a commonly prescribed medication for hypertension and angina, there are several alternative medications in the same class (calcium channel blockers) that may be used:

• Amlodipine (Norvasc)
• Verapamil (Calan, Isoptin)
• Nifedipine (Adalat, Procardia)
• Felodipine (Plendil)
• Nicardipine (Cardene)
• Isradipine (DynaCirc)
• Lacidipine (Lacipil)
• Nimodipine (Nimotop)

FAQs of TiazacWhat is the recommended dosage of Tiazac?The recommended dosage of Tiazac varies depending on the condition being treated and individual patient factors. It is typically started at 180 mg to 240 mg once daily for hypertension and chronic stable angina.How should I take Tiazac?Tiazac capsules should be swallowed whole and not crushed, chewed, or opened. They are usually taken once daily, preferably in the morning, with or without food.Can Tiazac be taken with food?Tiazac can be taken with or without food. However, it is essential to take it consistently, either always with food or always without food, to maintain consistent blood levels of the medication.What should I do if I miss a dose of Tiazac?If you miss a dose of Tiazac, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.How long does it take for Tiazac to start working?Tiazac may start working within a few hours of taking the first dose, but it may take several weeks for the full therapeutic effects to be achieved.Are there any dietary restrictions or interactions I should be aware of while taking Tiazac?Yes, Tiazac may interact with grapefruit juice, leading to increased drug levels and potentially adverse effects. As such, it is advisable to avoid grapefruit juice while taking Tiazac.Is it safe to drink alcohol while taking Tiazac?Alcohol may potentiate the blood pressure-lowering effects of Tiazac and increase the risk of side effects such as dizziness and lightheadedness. As such, it is advisable to limit or avoid alcohol consumption while taking Tiazac.