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Skyrizi Side Effects: What to Expect and How Long They Last
- Posted On:
- 2 Jul, 2026
- 9 min read
-
Introducing Skyrizi, the innovative self-injectable treatment that targets the root cause of plaque psoriasis, eczema, and psoriatic arthritis.Starting From $7,772.60
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Skyrizi is an injectable medication that is used to treat four different conditions. It is a brand name for risankizumab-rzaa. Patients can use this for treating psoriatic arthritis and psoriasis. It is also used to treat patients with Crohn’s disease or ulcerative colitis. It is a type of biologic medication. Skyrizi is approved for, and can be helpful, for treating many conditions. Skyrizi—like most other medications—has a long list of possible side effects. Patients should understand these side effects when determining if the medication is a good fit for them.
- Introducing Skyrizi, the innovative self-injectable treatment that targets the root cause of plaque psoriasis, eczema, and psoriatic arthritis.Starting From $7,772.60
10% Off On Your First Order
Click on the Copy Code button to copy your code.
No Expiry
Exclusive On Duty Free Meds Only
- Skyrizi is a biologic medication used to treat a variety of different conditions
- Common side effects may include joint pain, fatigue or headache, and reactions at the injection site
- Some patients may experience more serious side effects like allergic reactions or signs of liver problems
- Most mild side effects go away within a few days or weeks
- More serious side effects may last longer and need medical attention
Common Side Effects of Skyrizi
Patients taking Skyrizi may experience one or more of several different side effects. Some of these side effects are more severe than others. Most common side effects resolve themselves within a few days to a few weeks’ time. Some of the most common side effects include:
- Joint pain
- Headache
- Fever
- Back pain
- Fatigue
- Rash
- Abdominal pain
- Urinary tract infection
- Upper respiratory infections
- Redness or swelling at the injection site
- Itching at the injection site
- Anemia
- Fungal infections (like athlete’s foot)
Serious Side Effects and Risks
There are also some less common and more serious side effects of Skyrizi. Patients with these side effects should contact their doctor or seek medical attention right away. These side effects include:
- Allergic reactions (indicated by facial swelling or difficulty breathing)
- Itching
- Rash or hives
- Tightness in the chest
- Tightness of the throat or trouble breathing
- Low blood pressure
- Dizziness or fainting
- Indications of liver injury (such as dark urine or yellowing of the skin or eyes)
Skyrizi may also lower the patient’s ability to fight serious infections. This gives them a greater chance of developing infections like tuberculosis and pneumonia. Patients should be checked for these infections prior to starting their treatment. Patients experiencing any serious side effects should get medical attention immediately.
How Long Skyrizi Side Effects Last
Most mild side effects of Skyrizi go away within a few days. It may also be a few weeks in some cases. Serious side effects may last longer or become more severe over time. These serious side effects may require long-term medical treatment in some cases.
The exact length of the side effects may also be influenced by a few additional factors that are more specific to the patient. The patient’s personal health and any pre-existing conditions can have an effect on how long the side effects will last. Every patient may also have different responses to their overall treatment that could impact the length of their side effects.
The length of the side effects can also change if the patient is taking some other medications. Some medications may have interactions with Skyrizi and may cause symptoms more severe and last longer. These interactions can also lead to other adverse effects. Some interactions include live vaccines. Live vaccines can increase the chances of infection.
Patients on Skyrizi should also avoid medications that weaken their immune systems like corticosteroids and methotrexate. This also includes drugs like azathioprine and sulfasalazine. Patients should also avoid any supplements that weaken their immune system and other biologic medications while taking Skyrizi. All of these medications and vaccines can worsen or extend the side effects of Skyrizi.
Managing and Mitigating Side Effects
Patients experiencing side effects may be able to minimize those side effects in one of a few different ways. Those experiencing headaches or fatigue may be able to reduce the severity of their symptoms by making sure to drink plenty of water and getting enough rest.
Those who experience swelling may also be able to reduce this swelling by applying cold compresses to these areas. Fungal infections are another symptom that some patients may experience. The symptoms of this can be reduced by taking some over-the-counter treatments. Patients should also talk to their doctor before starting any new treatments. Their doctors may also be able to suggest new ways of safely reducing their symptoms.
Another way to avoid having side effects is by simply making sure the medication is being used correctly. Skyrizi injections are usually given by the doctor for at least the first few doses. Most Skyrizi prescriptions include two starting doses that are scheduled to be taken two weeks apart from one another. Patients usually get subsequent injections about every 12 weeks after. This usually continues long-term or until a doctor says otherwise. Sticking to this schedule as a doctor instructs can also help patients reduce their symptoms
When to Contact Your Healthcare Provider
The manufacturer tells patients to get emergency medical attention if they are experiencing signs of low blood pressure while taking Skyrizi. This may include symptoms like dizziness or fainting. Lightheadedness is also a sign of low blood pressure. The manufacturer also tells patients to get immediate medical attention if they experience any swelling in the face. This includes the lips and eyelids. It also includes the throat or mouth.
Tightness in the throat or chest and difficulty breathing are also signs that the patients need emergency medical attention. So are other signs of allergic reactions like rash or itching. Patients should also call for medical attention if any of the symptoms they experience while taking the medication will not go away or seem to be getting worse.
Patients should also reach out to their healthcare provider if they believe the medication is not working for them or believe they may have some resistance to the drug. Patients should always be open with their doctor about any concerns they have surrounding the medication and their symptoms as they arise.
Conclusion
Skyrizi can cause many different side effects. Some are more common than others. More severe side effects can occur but are less common. Making sure the medication is being taken as instructed and other daily changes may be able to help with the severity and duration of these side effects. Patients should continue monitoring their side effects throughout the duration that they are on the medication and let their healthcare provider know if they have any questions or concerns.
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Frequently Asked Questions (FAQs)
Can you develop long-term side effects from taking Skyrizi?
Some infections that can develop while taking the medication can have long-term effects. The condition of the patient and other medications they may be taking may also increase their risk of long-term symptoms.
What to avoid when taking Skyrizi?
This medication should be avoided for a while after a patient takes a live vaccine. Patients taking other biologics or medications that may lower the immune system should also avoid this medication. Some other supplements may also be risky to take while on Skyrizi. Patients should let their doctor know of any medications they are taking before starting their treatment.
Does Skyrizi cause any changes in weight?
Skyrizi is usually known to cause weight fluctuations. Weight loss while on the medication can be a sign of a serious infection.
Is Skyrizi bad for your liver?
This medication may cause liver damage in some cases. Patients should be on the lookout for yellowing eyes or skin and darkening urine. They should contact their doctor immediately if they have any of these symptoms.
Does Skyrizi impact your mood?
Skyrizi has not been shown to have an impact on mood in clinical studies. Psoriasis—one of the conditions this medication is used to treat—may increase the risk of depression.
Sources
Disclaimer: The information presented here is intended solely for educational purposes and should not be interpreted as medical advice, a diagnosis, or specific treatment recommendations. It does not imply endorsement of any particular medication or therapy. Health conditions and treatment responses can differ significantly between individuals; thus, this information is not a guarantee of safety, suitability, or effectiveness for anyone in particular. Always seek the guidance of a healthcare professional for personalized medical advice and consult them before making any health or treatment decisions.
