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Victoza (liraglutide) is a GLP-1 receptor agonist medication that is used to help type 2 diabetes patients lower their A1C and blood sugar levels. This medication also helps patients decrease their risk of suffering from cardiovascular events. This article will cover the dosing of Victoza and how to properly use the medication. It will also cover some additional safety considerations.
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| Patient Type | Step | Daily Dose | Notes |
|---|---|---|---|
| Adult Patients | Start | 0.6 mg | For at least 1 week to improve GI tolerability (non-therapeutic dose) |
| Maintain | 1.2 mg | For at least 1 week | |
| Titrate | 1.8 mg | For further glycemic control | |
| Pediatric Patients (10 Years or Older) | Start & Maintain | 0.6 mg | For at least 1 week to improve GI tolerability |
| Titrate | 1.2 mg | If additional glycemic control is needed | |
| Titrate Further | 1.8 mg | If more glycemic control is needed after ≥1 week on 1.2 mg |
The only form of this medication that is available is a prefilled injection pen. This medication is not like insulin vials or syringes and is not available in pill or tablet form. The only option is to inject this medication. Multiple subcutaneous injection doses are given through each of these pens. They are sold to patients in ready-to-use form – they just have to attach their disposable needle. These needles need to be changed for each injection (even if it comes from the same pen).
These pens should be kept in the patient’s refrigerator – at a temperature between 36 °F and 46 °F – until first use. The pen can be stored at room temperature after first use as long as it stays between 59°F and 86°F. However, the pen must be discarded after 30 days regardless of the expiration date or the amount of medication left after it has been opened. Pens should never be frozen. Pens that are frozen should be discarded.
All Victoza pens come in one strength – a concentration of 6 mg/mL. However, patients may buy pens in quantities of two each month if they are getting a lower dose or in quantities of three each month if they are getting a higher dose. Each pen can deliver between 10 and 30 doses depending on the prescribed dose amount. Each Victoza pen contains enough medication for 30 injections of 0.6 mg, 15 injections of 1.2 mg, or 10 injections of 1.8 mg.
The dose of the medication being taken from the pen can be adjusted using the dosing dial. Patients should only take the dose that was specifically prescribed to them. Having an understanding of the pen’s strength and how long each pen lasts helps patients plan refills and avoid running out.
Doctors usually start by prescribing patients a 0.6 mg dose of Victoza. This is considered a non-therapeutic dose for adults that is used to simply give their body time to adjust to the medication and minimize side effects. However, this is sometimes the only dose needed for pediatric patients. Pediatric patients prescribed this medication must be at least 10 years of age. Safety and efficacy of this medication have not been established for those under this age.
Victoza is injected once daily just under the skin as a subcutaneous injection. It can be administered in the abdomen, thigh, or upper arm (as directed by a healthcare provider). Patients should be sure to rotate injection sites with each dose to reduce irritation.
The Victoza pen is designed for use with NovoFine® or NovoFine® Plus 32-gauge needles. These are designed to be ultra-thin for a more comfortable experience. Always use a new needle for every injection and safely remove and discard it afterward to help prevent contamination/infection or leakage.
Patients should follow the “First-Time Use” instructions that come with the medication before using a new pen for the first time. This includes priming the pen to remove air and make sure that the pen is ready to deliver an accurate dose.
Patients should insert the needle straight into the skin when making the injection and press/hold the injection button. The needle will need to be kept under the skin for at least six seconds to make sure the full dose is delivered.
Victoza may be injected at any time of day whether or not food has been eaten. It is still best to use it at roughly the same time each day for consistent results. This medication is intended for subcutaneous use only and must not be injected into a vein or muscle. Each pen can be used daily until it is empty or for up to 30 days after first use once it has been started.
This medication is designed to be used long-term by the patient after it has been prescribed for their type 2 diabetes treatment. This is because the benefits of blood sugar control and the cardiovascular benefits depend on consistent use of the medication. This long-term use is considered to be safe for most patients as long as they undergo consistent monitoring. Their doctor may adjust their dose over time based on their response to the medication – such as how well the medication is working for their blood control and if they are experiencing any side effects.
The patient should keep in mind that their blood sugar levels will likely rise again if they stop taking Victoza. They should never stop taking this medication without being instructed to do so by their doctor or healthcare provider first. Patients’ doctors may review long-term therapy every few months to assess effectiveness and adjust the treatment plan if needed.
Patients who miss a dose of their Victoza medication should take their medication as soon as possible during the same day unless it is almost time for their next dose. It should be skipped in this case and the remainder of the dosing schedule should be proceeded with as normal. The 12-hour rule – where patients only take the medication if they remember to do so within 12 hours of missing their dose – can be helpful in determining if too much time has passed. Patients should never take an extra dose or double up on a missed dose.
Patients who have had more than three days pass since their last dose was taken should notify their doctor. They may have to reinitiate the dose at 0.6 mg again to give the body time to adjust and reduce the risk of adverse GI issues from occurring.
Serious side effects may occur if patients take more than their prescribed dose of Victoza. Studies have shown patients may get side effects from doing so such as epigastric abdominal pain or severe nausea. They may also get side effects of vomiting or hypoglycemia. Hypoglycemia from the medication is uncommon for patients to experience. However, it may be more likely to occur for patients who are combining this medication with the use of insulin or sulfonylureas. Signs that a patient has developed hypoglycemia include those such as:
Studies have also found that overdosing on liraglutide medications like Victoza may increase the likelihood of the patient developing pancreatitis – especially if abdominal pain becomes severe or persistent. Patients who think they have taken too much of this medication should closely monitor their blood sugar and treat any mild hypoglycemia they may develop with fast-acting carbs. The CDC suggests that patients follow the “15-15” rule. This involves consuming 15 grams of fast-acting carbs and rechecking blood glucose after 15 minutes. Patients should keep repeating this process until their level reaches at least 70 mg/dL. They suggest using foods and drinks such as:
Patients should contact their healthcare provider or their local poison control for additional guidance. Emergency care should be sought immediately if the patient begins to experience confusion or loss of consciousness. The same goes for if they begin to experience severe stomach pain. Patients should always double-check their dose before injecting it and never adjust their dose without a doctor’s instruction to do so.
Special monitoring and careful titration are important in several clinical settings.
No special doses are required to be given to patients who are aged 65 and above. However, this group of patients may be more sensitive to the medication. This is why it is best for this age group to start the medication slowly and closely monitor how it affects them.
The same goes for patients with kidney or liver issues. No special dose is required. However, these patients should be closely monitored to see how they are affected by the use of the medication. This medication should not be used in patients with end-stage kidney disease.
Patients may need to have their dose of the medication adjusted if they are taking sulfonylureas or insulin. Taking these medications together increases the risk of developing hypoglycemia.
This medication is not approved for use by patients with type 1 diabetes or diabetic ketoacidosis.
Patients on Victoza may develop some of the common side effects. These are more common when the patient first starts taking the medication and include:
Most of these symptoms should resolve on their own as the patient’s body adjusts itself to the medication. Some other less common side effects may also occur. These may include side effects like mild tachycardia or gallbladder disease. Reactions at the injection site may also occur in some cases. Patients can also reduce the likelihood of these side effects occurring by avoiding greasy foods and eating smaller food portions.
Some more serious side effects may also occur in rare cases. These require medical attention and may include:
Note: This medication is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or MEN 2.
Patients should call their doctor if they experience any of the serious side effects listed or if a common side effect will not go away on its own. They should also call for any side effects that become severe or if they have any questions.
The prefilled Victoza pen allows for a daily subcutaneous injection. The doses do not need to be coordinated with meals. However, patients are encouraged to use it at the same time each day to maintain steady blood sugar control. A single injection should be taken once daily with or without food. Recommended areas include the stomach, upper leg, or upper arm. Rotating injection sites helps reduce irritation and prevent skin complications. A new disposable needle must be attached for every injection. Pens should never be shared between patients (regardless of whether the needle has been changed).
Patients using these pens should also make sure to keep up with routine monitoring for the duration that they are using them. This includes routinely having HbA1c and renal function checked every three to six months for patients with diabetic kidney disease.
Patients may have a better experience with Victoza if they:
Patients should contact their doctor if they have common symptoms – like nausea or vomiting – that do not improve on their own over time. They should also call their doctor if they are experiencing pancreatitis or gallbladder problems. Patients should contact their doctor immediately if they notice any unexplained bumps appearing on their neck. These could indicate the formation of a thyroid tumor. Several missed doses that may call for readjustments of the patient’s dosing schedule is another reason to call the doctor.
Patients’ blood sugar levels and A1C can start to be lowered as soon as two weeks after starting the medication.
0.6 mg is considered a starting dose to reduce side effects and is not usually effective for blood sugar control. However, it may be enough in some pediatric patients.
Victoza’s primary use is for type 2 diabetes, with weight loss sometimes occurring as a side effect. Saxenda – which contains the same active ingredient at a higher dose – is specifically approved for weight management.
Patients should not exceed 1.8 mg of Victoza per day. Higher doses are discouraged.
Victoza can be injected at any time of day – morning or evening – as long as it is taken consistently around the same time each day.
Victoza is prescribed for type 2 diabetes management and cardiovascular risk reduction. Its dosing ranges from 0.6 mg to 1.8 mg once daily. Saxenda is approved for chronic weight management for patients who are overweight or obese and its dosing is higher – ranging up to 3 mg once daily.
It may be used with insulin or sulfonylureas. However, patients should be closely monitored since combining these treatments increases the risk of hypoglycemia. Separate injection locations should also be used.
Doctors prescribe patients lower doses of Victoza and increase them gradually for safety and effectiveness. It is important for patients to consistently take their medication and monitor how it affects them. Patients should always follow their doctor’s instructions and never adjust their own dose.
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ToggleDisclaimer: The information presented here is intended solely for educational purposes and should not be interpreted as medical advice, a diagnosis, or specific treatment recommendations. It does not imply endorsement of any particular medication or therapy. Health conditions and treatment responses can differ significantly between individuals; thus, this information is not a guarantee of safety, suitability, or effectiveness for anyone in particular. Always seek the guidance of a healthcare professional for personalized medical advice and consult them before making any health or treatment decisions.